The limited flash on the H750 should mostly be a non issue. My typical firmwares so far are barely over 128 kB all told, and I have a ton of executable RAM to work with.
So I can put a minimal bootloader and BSP (and maybe firmware update SFTP server) in the internal flash, bring up the FPGA, then copy my application image from spare space on the FPGA config flash to SRAM and jump to it.
The only other issue is that I normally run microkvs in the last few flash sectors. So in a single-sector flash part, I can't do that. Instead, I'd need to add a memory mapped interface to the FPGA-attached flash and store my config there. (I could also attach an extra QSPI flash to the MCU but that adds BOM cost, it's more pins to route, and most importantly involves dealing with the cursed OCTOSPI peripheral).
It'd take a bit of coding to get all of this done, but I think it's worth the effort. I may still go with the 753 for new designs long term but since I have 750s on the shelf, might as well use them up for one-off / low volume projects.
The larger BGA ball pitch alone is enough of a reason.